PDTD is a dual function database that associates an informatics database to a structural database of known and potential drug targets. PDTD is a comprehensive, web-accessible database of drug targets, and focuses on those drug targets with known 3D-structures. PDTD contains 1207 entries covering 841 known and potential drug targets with structures from the Protein Data Bank (PDB).
Drug targets of PDTD were categorized into 15 and 13 types according to two criteria: therapeutic areas and biochemical criteria.
The database supports extensive searching function using PDB ID, target name and category, related disease.Each record of drug target was prudently annotated by hyperlinks to other databases, such as DrugBank, TTD, ExPASy Proteomics Server and KEGG etc.
In conclusion, PDTD serves as the cornerstone for TarFisDock to identify the potential binding targets in-silico.
Distribution of targets by biochemical criteria
Distribution of targets in therapeutic areas
- Zhenting Gao, Honglin Li, Hailei Zhang, Xiaofeng Liu, Ling Kang, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Xicheng Wang & Hualiang Jiang. PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics 9:104 (2008) URL
- Honglin Li, Zhenting Gao, Ling Kang, Hailei Zhang, Kun Yang, Kunqian Yu, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Jianhua Shen, Xicheng Wang & Hualiang Jiang. TarFisDock: a web server for identifying drug targets with docking approach. Nucl. Acids Res. 34, W219-224 (2006) URL