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Chen Shuai
Ph.D Candidate
Email: schen@sibs.ac.cn getty@etang.com |
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EDUCATIONAL BACKGROUND¡¡ |
| 2002.9 ¨C now |
R&D Base, Shanghai Institutes for Biological Sciences, CAS |
| 1998.9 ¨C 2002.7 |
Biological Science, School of Life Sciences, Nanchang University |
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RESEARCH FOCUS |
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- Expression, purification and enzymatic activity characterization of SARS-CoV 3C-Like protease
- By the use of biochemical and biophysical techniques, for instance, gel filtration analysis, isothermal titration calorimetry (ITC), to explore SARS-CoV 3CL pro dimerization mechanism and identify the dimer's interface.
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PUBLICATIONS |
- Shuai Chen, Lili Chen, Jinzhi Tan, Jing Chen, Li Du, Tao Sun, Jianhua Shen, Kaixian Chen, Hualiang Jiang and Xu Shen, SARS Coronavirus 3CL pro N-terminus is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization: Biochemical and Thermodynamic Investigation in Conjunction with Molecular Dynamics Simulations J.Biol.Chem . 2005, 80: 164-173
- Shuai CHEN, Li-li CHEN, Hai-bin LUO, Tao SUN, Jing CHEN, Fei YE, Jian-hua CAI, Jing-kang SHEN, Xu SHEN and Hua-liang JIANG. Enzymatic activity characterization of SARS coronavirus 3C-like protease (3CL pro ) by fluorescence resonance energy transfer (FRET) technique. Acta.Pharmacol.Sin .2005, 26: 99-107
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