Education and training background

2008-present Associate Prof. of DDDC, SIMM, CAS

2005-2008 PDF in Marmorstein’s Lab, The Wistar Institute, Upenn

2004-2005 Assistant Prof. of DDDC, SIMM, CAS

2001-2004 Ph.D. Candidate of Organic Chemistry, SIMM, CAS

1998- 2001 Chem. Dept., Fudan University, Major in Theoretical Chem., M.S.

1990- 1994 Dept.of Chem., Fuzhou University, B.S.

Research Interests

My research interests are in those epigenetic related enzymes that regulate gene expression; anti-bacterial or virus drug design and a few kinase signaling pathways. We are particularly interested in exploring the mechanism of posttranslational modification, gene regulatory proteins and their upstream signaling kinases that are aberrantly regulated in tumor or related diseases. We use a series of theoretical and experimental drug design strategies towards the development of protein-specific small-molecule (especially Chinese Natural Products) to further probe the protein function, and for the development into therapeutic agents.

PUBLICATIONS (List in chronological order; ^ indicates equal contribution, * indicates corresponding author)：

1. Zhongjie Liang, Jiahui Wu, Sisheng Ouyang, Lianchun Li, Liming Chen, Hualiang Jiang, Dongxiang Liu, and Cheng Luo*, Structural basis for the deacetylation mechanism and Zn2+-binding motif dependent substrate binding affinity of SIRT1 by computational analysis and biological experiments, Journal of Molecular Biology, to be submitted.
2. Juxian Wang, Limin Chen, Sarmistha Halder Sinha, Huifang Cai, Keqin Kathy Li, Hualiang Jiang, Yujun George Zheng and Cheng Luo*, Pharmacophore-Based Virtual Screening and Biological Evaluation of Histone Arginine Methyltransferase PRMT1 Inhibitors with Novel Inhibitory Mechanism, Journal of Medicinal Chemistry, to be submitted.
3. Yongxiang Wang, Cheng Luo, Dan Zhao, Jürgen Beck, Michael Nassal, Extensive mutational analysis of primer grip motif of duck hepatitis B virus polymerase reveals multiple functions and a common structure with HIV-1 RT, Nucleus Acid Research, submitted.
4. Junyan Lu, Xiangqian Kong, Cheng Luo* & Keqin Kathy Li, Application of Epigenetic Small Molecules in Induced Pluripotent Stem Cells, Medicinal Research Review, submitted.
5. Liang Zhang, Xingyu Lu, Junyan Lu, Haihua Liang, Qing Dai, Guo-Liang Xu, Cheng Luo, Hualiang Jiang & Chuan He, TDG preferentially recognizes 5-carboxylcytosine as revealed by TDG/DNA structure, Nature Chemical Biology, revised.
6. Junfeng Jiang, Junyan Lu, Dan Lu, Lianchun Li, Sisheng Ouyang, Xiangqian Kong, Zhongjie Liang, Hualiang Jiang, Bairong Shen and Cheng Luo*, Investigation of the acetylation mechanism by GCN5 Histone Acetyltransferase, PLoS ONE, revised.
7. Shuai Wang, Xun Huang, Danni Sun, Xianliang Xin, Qiuming Pan, Shuying Peng, Zhongjie Liang, Cheng Luo, Yiming Yang, Hualiang Jiang, Min Huang, Wengang Chai, Jian Ding, Meiyu Geng, Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling, PLoS ONE, submitted.
8. Xu Li, Ching-Ying Kuo, Jeremy Stark, Xiang-Qian Kong, Cheng Luo, Shikha Gaur, Mong-Hong Lee, Yun Yen, Hsiu-Ming Shih, Sai-Juan Chen, Keqin Kathy Li and David K. Ann, Phosphorylation Promotes a STUbL RNF4-dependent Modulation of KAP1 Function in Responses to DNA Damage, Molecular Cell, revised.
9. Jun-Mian Tian, Si-Sheng Ou-Yang, Xu Zhang, Ying-Tong Di, Hua-Liang Jiang, Hong-Lin Li, Wei-Xing Dai, Ke-Yu Chen, Mai-Li Liu, Xiao-Jiang Hao, Yun-Heng Shen, Cheng Luo* and Wei-Dong Zhang, Experimental and Theoretical Insights into the Conformations of Tunicyclin E, A New Cycloheptapeptide from Psammosilene tunicoides: Intramolecular Catalysis of Cis/Trans Isomerization of Peptidyl-prolyl Bond, RSC Advance, in press.
10. Zhongjie Liang, Xiao Ding, Jing Ai, Limin Chen，Hengshuai Wang, Xiangqian Kong, Lianchun Li, Fei Ye, Sisheng Ouyang, Hong Liu, Cheng Luo*, Meiyu Geng, Hualiang Jiang, Kaixian Chen, Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay, Organic & Biomolecular Chemistry, 2012, 10, 421-430.
11. Liang Chen, Xiangqian Kong, Zhongjie Liang, Fei Ye, Kunqian Yu, Weiyi Dai, Daocheng Wu, Cheng Luo*, Hualiang Jiang, Theoretical study of the mechanism of proton transfer in the esterase EstB from Burkholderia gladioli, Journal of Physical Chemistry B, 2011, 115 (44), 13019–13025.
12. Xiangqian Kong, Sisheng Ouyang, Zhongjie Liang, Junyan Lu, Liang Chen, Bairong Shen, Donghai Li, Mingyue Zheng, Keqin Kathy Li, Cheng Luo*, Hualiang Jiang, Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A computational study, PLoS ONE, 6(9): e25444
13. Jie Zhang, Fei Ye, Lefu Lan, Hualiang Jiang, Cheng Luo*, Cai-Guang Yang, Structural Switchings Of Staphylococcus Aureus ClpP: A Key To Understanding Protease Mechanism, Journal Biological Chemistry, 286(43):37590-601
14. Zhongjie Liang, Lianchun Li, Yuanyuan Wang, Limin Chen, Xiangqian Kong, Yao Hong, Lefu Lan, Mingyue Zheng, Cai-Guang Yang, Xu Shen, Cheng Luo*, Keqin Kathy Li, Kaixian Chen and Hualiang Jiang, Molecular basis of NDM-1, a new antibiotic resistance determinant, PLoS ONE, 6(8): e23606
15. Zhongjie Liang, Dengyou Zhang, Jing Ai, Limin Chen，Hengshuai Wang, Xiangqian Kong, Hong Liu, Cheng Luo*, Meiyu Geng, Hualiang Jiang, Kaixian Chen, Identification of N'-(2-oxoindolin-3-ylidene) hydrazide derivatives as c-Met Kinase Inhibitors, Bioorganic Medicinal Chemistry Letter,2011, 21(12), 3749-54
16. Zhongjie Liang, Liying Zhang, Lianchun Li, Jun Liu, Hongling Li, Luyong Zhang，Limin Chen, Keguang Cheng, Mingyue Zheng, Xiaoan Wen, Pu Zhang, Jia Hao, Yanchun Gong, Xia Zhang, Xiaoyun Zhu, Jun Chen, Hong Liu, Hualiang Jiang, Cheng Luo* and Hongbin Sun, Identification of Pentacyclic Triterpenes Derivatives as Potent Inhibitors against Glycogen Phosphorylase based on 3D QSAR studies, European Journal Medicinal Chemistry, 2011 46(6), 2011-21.
17. Yifei Tang, Jiajia Chen, Cheng Luo, Antti Kaipia and Bairong Shen, microRNA expression analysis reveals significant biological pathways in human prostate cancer, IEEE International Conference on Systems Biology, 2011, 203-210.
18. Mingyue Zheng, Bing Xiong, Cheng Luo, Shanshan Li, Xian Liu, Qianchen Shen, Jing Li, Weiliang Zhu, Xiaomin Luo, Hualiang Jiang, Knowledge-based Scoring Functions in Drug Design: 3. A Two-Dimensional Knowledge-Based Hydrogen-Bonding Potential for the Prediction of Protein-Ligand Interactions, Journal of Chemical Information and Modeling, 2011, 51(11):2994-3004
19. Fei Wang, Dongxiang Liu, Heyao Wang, Cheng Luo, Minyue Zheng, Hong Liu, Weiliang Zhu, Xiaomin Luo, Jian Zhang & Hualiang Jiang, Computational screening active compounds targeting protein sequences: methodology and experimental validation, Journal of Chemical Information and Modeling, 2011, 51 (11), 2821–2828.
20. Qiancheng Shen, Bing Xiong, Mingyue Zheng, Xiaomin Luo, Cheng Luo, Xian Liu,Yun Du, Jing Li, Weiliang Zhu, Jingkang Shen and Hualiang Jiang, Knowledge-Based Scoring Functions in Drug Design: 2. Can the Knowledge Base Be Enriched? Journal of Chemical Information and Modeling, 2011, 51(2):386-97.
21. Kathy Keqin Li^, Cheng Luo^, Donxia Wang, Hualiang Jiang, Yujun George Zheng, Chemical and biochemical approaches in the study of histone methylation and demethylation, Medicinal Research Review, 2010, DOI: 10.1002/med.20228.
22. Huifang Chai, Chunshen Zhao, Lin Li, Ping Gong, Zhongjie Liang, Weiliang Zhu, Hualiang Jiang, Cheng Luo*, Identification of novel 5-hydroxy-1H-indole-3-carboxylates with anti-HBV activities based on 3D QSAR studies, Journal of Molecular Modeling, 2011, 17(8):1831-40.
23. Ning Li, Scott Thompon, Hualiang Jiang, Paul M Libermann, Cheng Luo*, Development of drugs for Epstein-Barr virus using highthroughput in silico screening, Expert Opinion on Drug Discovery, 2010, 5(12):1189-1203..
24. Sergio E. Alvarez, Kuzhuvelil B. Harikumar, Nitai C. Hait, Jeremy Allegood, Graham M. Strub, Eugene Kim, Michael Maceyka, Hualiang Jiang, Cheng Luo, Tomasz Kordula, Sheldon Milstien, & Sarah Spiegel, Sphingosine-1-phosphate: a missing Cofactor for the E3 Ubiquitin Ligase TRAF2, Nature, 465(2010), 1084-8.
25. Ning Li, Scott Thompson, David C. Schultz, Weiliang Zhu, Hualiang Jiang, Cheng Luo* and Paul M. Lieberman*, Discovery of specific inhibitors against EBNA1 via high throughput in silico virtual screening, PLoS ONE, 5(4)(2010), e10126.
26. Zhongjia Liang, Ti Shi, Liangchun Li, Cheng Luo* ,Hualiang Jiang, The Investigation on the Catalytic Mechanism of Sir2 Enzyme with QM/MM Approach: SN1 vs SN2?, Journal of Physical Chemistry B, 114(2010), 8487–93.
27. Fei Ye, Xiangqian Kong, Cheng Luo*, Advance In the Study of Mechanisms regulatd by Sphingosine-1-Phosphate, Bulletin of National Natural Science Foundation of China, 2010, 18(1), 57-60
28. 叶飞，孔祥谦，罗成*，鞘氨磷酸脂调控机制的研究进展, 中国科学基金, 2010, 24(5), 279-82
29. Yu Zhou, Chunyi Jiang, Yaping Zhang, Zhongjie Liang, Wenfeng Liu, Cheng Luo, Tingting Zhong, Yi Sun, Linxiang Zhao, Hualiang Jiang, Naiming Zhou, Dongxiang Liu, and Hong Liu, Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors, Journal of Medicinal Chemistry, 53 (15)(2010), 5449–66.
30. Guangrong Qin, Kunqian Yu, Ting Shi, Guohui Li, Cheng Luo, Weiliang Zhu, Hualiang Jiang, How Does Influenza A Virus Escape From Amantadine? Journal of Physical Chemistry B, 114(2010), 8487-8493.
31. Xiaofeng Liu, Hua Xie, Cheng Luo, Linjiang Tong, Yi Wang, Ting Peng, Jian Ding, Honglin Li and Hualiang Jiang, Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening, Journal of Medicinal Chemistry, 53(2010), 2661-5.
32. Kunqian Yu^, Cheng Luo^, Guanrong Qin，Zijian Xu, Hong Liu, Xu Shen, Jianpeng Ma, Qinghua Wang，Caiguang Yang, Weiliang Zhu, Hualiang Jiang. Why Tamiflu and Zanamivir works on Influenza A (H1N1)?, Cell Research 2009, 1038.
33. Yu Feng, Jiahui Wua, Lei Chen, Cheng Luo, Xu Shen, Kaixian Chen, Hualiang Jiang, Dongxiang Liu, A fluorometric assay of SIRT1 deacetylation activity through the quantification of nicotinamide adenine dinucleotide, Analytical Biochemistry, 395(2)(2009),205-1.
34. Nitai C. Hait, Jeremy Allegood, Michael Maceyka, Graham M. Strub, Kuzhuvelil B. Harikumar, Sandeep K. Singh, Cheng Luo, Ronen Marmorstein, Tomasz Kordula, Sheldon Milstien, Sarah Spiegel, Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate, Science, 325(2009),1254-7.
35. Chao Zhang, Na Yang, Chun-hao Yang, Hua-sheng Ding, Cheng Luo, Yu Zhang, Mao-jiang Wu,Xiong-wen Zhang, Xu Shen, Hua-liang Jiang, Ling-hua Meng, Jian Ding, S9, a Novel Anticancer Agent, Exerts Its Anti-Proliferative Activity by Interfering with Both PI3K-Akt-mTOR Signaling and Microtubule Cytoskeleton, PLoS ONE 4(3)(2009), e4881.
36. Cheng Luo, Peng Xie, Ronen Marmorstein. In silico screening of BRAF inhibitors, Journal of Medicinal Chemistry, 9;51(2008), 6121-7.
37. Yong Tang, Katrina Meeth, Eva Jiang, Cheng Luo and Ronen Marmorstein. Structure of Vps75: Implications for Histone Chaperone Function, Proceedings of the National Academy of Sciences, 105 (2008), 12206-11.
38. Manqing Hong, Mary X Fitzgerald, Sanders Harper, Cheng Luo, David W Speicher and Ronen Marmorstein, Structural Basis for Dimerization in DNA Recognition by Gal4. Structure, 16(7)(2008), 1019-26.
39. Liang Zhang, Weizhi Liu, Tiancen Hu, Li Du, Cheng Luo, Kaixian Chen, Xu Shen, and Hualiang Jiang, Structural Basis for Catalytic and Inhibitory Mechanisms of beta-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ),Journal of Biological Chemistry, 283(9)(2008), 5370-79.
40. Yong-Xiang Wang, Xiang Xu, Cheng Luo, Zhang-Mei Ma, Hua-Liang Jiang, Jian-Ping Ding, Yu-Mei Wen, Mutational analysis revealed that conservation of hepatitis B virus reverse transcriptase residue 306 (rtP306) is crucial for encapsidation of pregenomic RNA, FEBS Letters, 581 (2007), 558-64.
41. Hanjun Zou, Cheng Luo, Suxin Zheng, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Jianhua, Shen, Hualiang Jiang, Molecular insight into the interaction between IFABP and PA by using MM-PBSA and alanine scanning methods, Journal of Physical Chemistry B 111 (2007), 9104-13.
42. Yong-Xiang Wang, Xiang Xu, Cheng Luo, Zhang-Mei Ma, Hua-Liang Jiang, Jian-Ping Ding, and Yu-Mei Wen. A Putative New Domain Target for Anti-Hepatitis B Virus: Residues Flanking epatitis B Virus Reverse Transcriptase Residue 306 (rtP306) Journal of Medical Virology 9999(2007), 1-7.
43. William C. Ho, Cheng Luo, Kehao Zhao, Xiaomei Chai, M.X. Fitzgerald and Ronen Marmorstein. High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds, Acta Crystallographica Section D, 62(2006), 1484-93.
44. Lili Cheng, Jian Li, Cheng Luo, Hong Liu, Weijun Xu, Gang Chen, QiWah Liew, Weiliang Zhu, Chum Mok, Puah, Xu Shen, Hualiang, Jiang, Binding interaction of quereetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): Structure-activity relationship studies reveal salient pharmacophore features, Bioorganic Medicinal Chemistry 14(2006), 8295-306.
45. Hongwei Jin, Suxin Zheng, Zhanli Wang, Cheng Luo, Jianghua Shen, Huajiang Jiang, Liangren Zhang, Lihe Zhang, Structural insights into the effect of isonucleosides on B-DNA duplexes using molecular-dynamics simulations, Journal of Molecular Modeling 12(2006), 781-91.
46. Cheng Luo, Lingfei Xu, Suxing Zheng, Jianhua Shen, Hualiang Jiang, et al. Computational Analysis of Molecular Basis of 1:1 Interactions of NRG-1b Wild-Type and Variants with ErbB3 and ErbB4, Proteins, 59 (2005),742-56.
47. Weiliang Zhu, Gang Chen, Lihong Hu, Xiaomin Luo, Chunshan Gui, Cheng Luo, Chum Mok Puah, Kaixian Chena and Hualiang Jianga, QSAR analyses on ginkgolides and their analogues using CoMFA, CoMSIA, and HQSAR, Biooranic Medicinal Chemistry Letters 13 (2005) 313-22.
48. Weizhi Liu, Cheng Luo, Cong Han, Shuying Peng, Yiming Yang, Xu Shen and Hualiang Jiang. b-Hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: molecular cloning, stability characterization and structural modeling. Biochemical and Biophysical Research Communications, 333 (2005) 1078-86.
49. Cheng Luo, Haibin Luo, et al., Nucleocapsid protein of SARS coronavirus tightly binds to human Cyclophilin A, Biochemical and Biophysical Research Communications, 321(2004), 557-65.
50. Gang Chen, Xiaomin Luo, Weiliang Zhu, Cheng Luo, Hong Liu, Chum Mok Puah, Kaixian Chen and Hualiang Jiang, Elucidating inhibitory models of the inhibitors of epidermal growth factor receptor by docking and 3D-QSAR, Bioorganic & Medicinal Chemistry, 12 (2004), 2409-17.
51. Yong Xu, Hong Liu, Chunying Niu, Cheng Luo, Xiaomin Luo, Jianhua Shen, Kaixian Chen and Hualiang Jiang, Molecular docking and 3D QSAR studies on 1-amino-2-phenyl-4-(piperidin-1-yl)-butanes based on the structural modeling of human CCR5 receptor, Bioorganic & Medicinal Chemistry, 12 (2004), 6193–208.
52. Dong Shao, Chunyan Zou, Cheng Luo, Xican Tang and Yuanchao Li, Synthesis and evaluation of tacrine–E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer’s disease, Bioorganic & Medicinal Chemistry Letters, 14(2004) 4639-42.
53. Xiao-Jing Yu, Cheng Luo, et al. Putative hAPN receptor binding sites in SARS_CoV spike protein, Acta Pharmacol Sin, 24 (6) (2003), 481-8.
54. Bin Xiong, Chun-Shan Gui, Xiao-Ying Xu, Cheng Luo, et al. A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening, Acta Pharmacol Sin, 24 (6) (2003), 497-504.
55. Lei Qin, Bin Xiong, Cheng Luo, et al. Identification of probable genomic packaging signal sequence from SARS-CoV genome by bioinformatics analysis, Acta Pharmacol Sin, 24 (6) (2003): 489-96.
56. Cheng Luo, Wen-Ning Wang, Ming-Hua Qiao, Kang-Nian Fan, Adsorption of sulfur on NimB2 clusters: a theoretical investigation on the mechanism of strong sulfur resistance of Ni-B alloy catalyst, Journal of Molecular Catalysis A: Chemical, 184(2002), 379-86.
57. Cheng Luo, Bai-Rong Shen, Kang-Nian Fan, Theoretical Study on the Local Structure and Properties of Electron Transfer of Ni-B Amorphous Alloy, Acta Chimica Sinica, 58:8(2000), 948-52.

PATENTS

1. 专利名称：新型胺基吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途（专利申请受理）；申请号：201110079133.9；申请日:2011年3月30日；申请人：中国科学院上海药物所；发明人：柳红、耿美玉、罗成、张登友、艾菁、梁中洁、王英、蒋华良、陈凯先
2. 专利名称：取代的酰肼类化合物及其制备方法、药物组合和用途，（专利申请受理）；申请号：201110124762.9；申请日：2011；申请人：朱维良，曾步兵，王贺瑶，闫桂蕊，黄贤贵，徐志建，罗成，张奇军，王改红，杨卓，张小东,李波，徐炜均，罗小民，蒋华良，陈凯先
3. 专利名称：一类喹喔啉衍生物及其制备方法和用途；发明人：蒋华良, 沈旭, 左建平, 白东鲁, 沈竞康, 沈建华, 罗小民, 桂春山, 罗成, 杨以阜, 郭虹霞, 陈晴,刘学军, 王峰,胡仲良,杨勤刚,蔡茂军,张莉,王昕,庄贤韩 CN1590378, 2003/8/29专利
4. 专利名称：五羟黄酮－3－β－半乳糖苷的医药用途及其制剂；朱维良, 潘春木, 陈莉莉, 沈旭, 陈刚, 罗成, 徐炜均, 罗小民, 柳红, 沈建华, 陈凯先, 蒋华良CN1830449, 2005/3/11，专利
5. 专利名称：3-烷氧取代-2，5，7-三取代苯并吡喃-4-酮类化合物及其制备方法和包含该类化合物的药物组合物（专利申请受理）申请号：200510132956.8;申请日：2005年12月29日; 申请人：中国科学院上海药物研究所、新加坡理工学院; 发明人：朱维良、李剑、陈莉莉、潘春木、罗成、陈刚、左之利、罗小民、沈旭、陈凯先、蒋华良
6. 专利名称：饱和五、六或七元环并吡啶类化合物的合成及其药用活性申请号：200610023275.2;申请日：2006年1月12日; 申请人：中国科学院上海药物研究所; 发明人：蒋华良、沈旭、柳红、沈建华、罗小民、姚志艺、陈静、罗成、左之利、杜丽、陈凯先
7. 专利名称：Benzopyranone derivatives and their use as anti_viral agents 专利号：200606408-3（新加坡申请）; 申请日：2006年9月27日; 国际申请号：PCT/SGA2006000392;申请日：2008年8月1日申请人：新加坡理工学院(SINGAPORE POLYTECHNIC)、中国科学院上海药物研究所; 发明人：PUAH Chum Mok、朱维良、李剑、陈莉莉、罗成、陈刚、左之利、罗小民、沈旭、陈凯先、蒋华良
8. 专利名称：四氢喹啉类化合物、其制备方法及药物组合物专利号：200710037660.7;申请日：2007年2月16日申请人：中国科学院上海药物研究所、魏茨曼科学研究所; 发明人：蒋华良、沈旭、柳红、罗小民、姚志艺、陈静、罗成、周宇、黎陈静、左之利、杜丽、陈凯先、乔?L.沙斯曼、伊斯瑞尔?西尔曼、泰伦?L.罗森伯瑞、约瑟夫?L.约翰逊、哈里?M.格林布莱特、泰泽维亚?兹-本-莫德柴
9. 专利名称：肉桂酸脂类化合物及其在制备白三烯水解酶功能调节药物中的应用专利号：200910047188.4;申请日：2009-3-6;申请人：中国人民解放军第二军医大学; 发明人：张卫东、蒋华良、单磊、李洪林、沈云亨、罗成