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张健
Jian Zhang
Ph.D
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Educational Background |
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| Sept. 2007-Present |
Research Fellow
Drug Design
Hematology/Oncology Department, University of Michigan, Ann Arbor. |
| Sept. 2002-June 2007 |
Ph.D.
Drug Design.
Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Thesis:
1. Leads design and structural modification on kinase
2. Mechanism study of inhibtor or activator on kinase.
3. Preidiction of protein-protein interactional Network.
4. Binding free energy calculation between ligand and receptor.
5. Virtual Combinatorial Libarry & De novo method development.
Supervisor: Prof. Hualiang Jiang |
| Sept. 1997-July 2002 |
B.S.
Pharmacology.
Dept. of Pharmacology, Peking University, China. |
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Research Experiences |
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- Designed Conjuate-Triad descriptor on sequences of proteins. Preidicted protein-protein interactional network solely by sequence information using novel bi-comparison kernel based SVM. Programmed on the whole suite using C++ language.
- Designed sequence-based virtual screening method. Constructed public web-server in identifying partners.
- Developing de novo method in structure-based drug design, programming the whole suite of software using C++ language, including site detection, fragments extraction from CMC database, fragments combination in the binding site of target, etc
- Target dynamic simulations on mechnism for activator of? glucokinase. Evaluated essential move modes by Nomal mode analysis, free energy calculation of binding by MMPBSA-Nmode method and mutation effect by alanine scan
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Publications |
- Jian Zhang, Chenjing Li, Kaixian Chen, Weiliang Zhu, Xu Shen, Hualiang Jiang. Conformational transition pathway in the allosteric process of human glucokinase, Proc. Natl. Acad. Sci. USA . 2006，103(36),13368-13373.
- Juwen Shen1, Jian Zhang1 (1 are contributed equally to this work), Xiaomin Luo, Weiliang Zhu, Kunqian Yu, Yixue Li, Hualiang Jiang. Predicting protein-protein interactions based only on sequences information. Proc. Natl. Acad. Sci. USA., 2007,104(11),4337-4341.
- Jian Zhang, Yechun Xu, Jianhua Shen, Xiaomin Luo, Jiagao Chen, Kaixian Chen, Weiliang Zhu, and Hualiang Jiang. Dynamic Mechanism for the Autophosphorylation of CheA Histidine Kinase: Molecular Dynamics Simulations, J. AM. CHEM. SOC., 2005, 127(33), 11709-11719.
- Shuai Chen1, Tiancen Hu1, Jian Zhang1(1 are contributed equally to this work), Jing Chen, Kaixian Chen, Hualiang Jiang, and Xu Shen. Mutation of Gly11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of SARS-CoV 3CLpro: Crystal Structure in Conjunction with Molecular Dynamics Simulations, J.Biol.Chem. in press
- Jian Zhang, KunQian Yu, Weiliang Zhu, Hualiang Jiang. Neuraminidase pharmacophore model derived from diverse classes of inhibitors, Bioorg. Med. Chem. Lett., 2006, 16(11), 3009-3014.
- Jian Li1, Jian Zhang1(1 are contributed equally to this work), Jing Chen, Xiaomin Luo, Weiliang Zhu, Jianhua Shen, Hong Liu, Xu Shen, Hualiang, Jiang. An Effective Strategy for Discovering Novel Chemical Inhibitors of Human Cyclophilin A: Focused Library Design, Virtual Screening, Chemical Synthesis and Bioassay, J. Comb. Chem. , 2006, 8(3), 326-337.
- Zhiqiang Qin1, Jian Zhang1(1 are contributed equally to this work), Bin Xu, Lili Chen, Yang Wu, Yuanzhu Ou, Xiaomei Yang, Xu Shen, Hualiang Jiang, Di Qu. Structure-based discovery of inhibitors of the YycG histidine kinase: New chemical leads to combat Staphylococcus epidermidis infections. BMC MICROBIOL., 2006, 6, 96-114.
- Cong Han1, Jian Zhang1(1 are contributed equally to this work), Lili Chen, Kaixian Chen, Xu Shen, Hualiang Jiang. Discovery of Helicobacter pylori shikimate kinase inhibitors: bioassay and molecular modeling. Bioorg. Med. Chem. ,2007, 15(2), 656-662.
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